0:02
And this issue of Dr. Blair like reports, it's the third in the series of videos on the 90-minute discussion on this topic, broken into three 30-minute sections, and this is on the antioxidant
0:18
system to counter immunoexciter toxicity
0:24
This video she lasts 38 minutes, and it's on microglial activation, and the second part is on the summary of the entire series, and also attention to the pharmaceutical industry and its position in
0:41
regard to supplements.
0:45
Also, this is, as you were getting into describing how these things happen, these are these free radicals, this is a reactive oxygen species or other reactive species like nitrogen species
0:59
and so forth. They're a product of these, this tremendous number of metabolic reactions going on in the mitochondria. And when they go on, these are the things that cause the chemical reactions
1:12
throughout the cell on the body to become unstable and they can lead to tumor effects and other toxic effects. And that's what you were getting to. Do you wanna make a comment about this before I go
1:24
to the next slide that you made on the microglia?
1:29
Yeah, and basically what you have, ROS and RNs, reactive oxygen species and reaction nitrogen species. And what a lot of people don't understand is that when the body produces a superoxide radical,
1:46
it's fairly mild radical to a moderate radical, but it combines with nitric oxide to form peroxy nitrite, which is one of the most powerful free radicals We find an Alzheimer's disease, we find it
2:01
in heart disease, we find it in a lot of diseases, high levels of
2:08
peroxynitrite. Well, not many things neutralize peroxynitrite, and curcuminous is one that will neutralize it. So we'll coerce it in
2:18
the cations that we discussed. They neutralize that radical. Well, here you're seeing a microglia that has become activated And normally, the microglia are resting in your brain. They're
2:31
scattered heterogeneously throughout the brain. And they send out these little pseudopodia, those little parts of the cell that you see sticking out here. And normally, they're tasting and
2:46
chemically testing the environment to make sure there's nothing out there that's going to cause them trouble, particularly glutamine if there's a.
2:57
and irritation of the microglia, anything, even systemically in the rest of your body. Immediately, within a minute, the microglia in the brain and the spinal cord will be activated. When it's
3:12
activated, all it's enzymes that are bloosing these toxic elements is increased. Initially, we see an increased generation of glutamate. We see an increase in the inflammatory
3:25
cytokines, particularly, we're in a lukem-1 beta, TNF alpha in a lukem-6, and in a lukem-2. And then we see a special inflammatory chemical called quinilinic acid, and we see arachnodonic acid.
3:39
All of these things are inflammatory chemicals. They produce inflammation in the surrounding area, and they produce these reactive oxygen and nitrogen species, which are the pre-radical.
3:56
So, I have on the left side of that slide, the peroxide nitrate, on the right side lipid peroxidation, which what happens is the reactive oxygen, nitrogen species, react with the fan in the cell
4:10
and will produce these lipid peroxidation products, which are also damaging. And those will also affect the mitochondrion in the brain cell, neuron cell produce dysfunction of that mitochondria.
4:29
So it's no longer functioning right. It's not producing enough energy. Well that has effect on the person of the whole and has effect on whatever organ that happens to be in. If it's in the brain,
4:41
their brain is affected. It's in the heart, the heart, and the liver, and the pancreas, and the kidneys. So we see that it's interfering with the ability of the the mitochondria. not only to
4:55
produce energy, but also to control the calcium content. And then you have acceleration of exciter toxicity by that activation. And I've coined this name immuno-exciter toxicity and I've introduced
5:13
it in a number of articles, which is now being widely discussed. And several people have said, there's no question it's the cause of
5:23
Alzheimer's disease. And now they're looking at
5:28
Parkinson's disease and saying, well, there's no question, but immuno-exciter toxicity is causing. And that's because the immune system intimately connects to the release of glutamate, which is
5:41
an exciter toxin. It excites brain cells to produce more free radicals, more damage, and eventually will kill the cell Uh huh. So that's what we're seeing in these neurodegenerative diseases.
5:55
Well, we also found there's glutamate receptors in every organ in the body, every tissue, heart, lung, kidneys, testes, everything. And if you have high levels of glutamate produced by these
6:06
cells, it will produce excitotoxic to destroy the
6:13
cell. Well, you don't have microglia in the liver and the pancreas, but you'd have a macrophage. A macrophage acts just like a microglia.
6:26
It produces glutamate. It produces inflammatory cytokines. They interact to drastically produce damage inside the cell and can kill the cell. That seems to be the basis of most of these diseases
6:43
and destruction of the brain and destruction of the organs and tissues Is this production of this immuno-excited toxicity? Let me make a statement here is the other day I was working with some papers
6:57
and I got a paper cut and you know everybody gets it has gotten a paper cut you know usually it's like a knife slice deep deep and it's painful and it's a very it's just like the paper it's like a
7:11
very thin slice and I watch this over a period of time and I saw that around this this cut there was a intense amount of redness which is inflammation which is the blood vessels dilating and all these
7:28
microglia are peripheral white cells entering in the area because there's been damage just like you said and now they're highly active and there had to be if there wasn't one cell like we're seeing
7:40
this picture there must have been thousands if not millions in there that were attracted to this area and there are signals that go out to the rest of the shells in the body to come and help me out
7:52
here. I need some more troops here to offset this damage. And so with that, you bring good things, you bring bad things into it. And those are what you were mentioning. It brings more glutamate
8:04
in, it brings more cytokines in there, which are sending signals to the cell to do various things and other things. And then we've got more chemical reactions producing more free radicals leading
8:16
to damage. And so it's a conscious, constant yin and yang and
8:21
eventually the swelling and the redness went down and the finger was warm. Everybody's gone through this in their life. And that was, I couldn't see it with a microscope, but I knew that was what
8:33
was happening. And so what you've described here in this picture is one cell and you're talking about, we're back to 40 trillion cells and above 40 trillion cells in a body where this immense number
8:45
of reactions are going on. And let's say we attack one part of the body, you get this whole series of reactions that occur that produces an immune reaction. If the body is successful, it quells it.
8:58
If it's not successful, and this is gonna get into what I wanted you to talk about, which is activation of the white cells. Because you may, obviously, the cut and the finger went away. But if
9:12
I'm like a boxer and I'm in a boxing ring and you wrote your paper 20 years ago about this, and they constantly get him hit in the head, which are trauma to the nerve cells and to the cells around
9:24
there, this reaction is being recurring and recurring. You wanna talk about micro glial activation and how that happens and what can we do to stop it? And that gets gonna get back to all the
9:38
flavonoid and antioxidants.
9:41
Yeah, basically what they discovered which is calledsignance behavior. is when you catch a flu or some other infection like the flu,
9:54
you immediately go through these neuropsychiatric problems. You don't want to sleep a lot, you don't want to socialize, you have difficulty thinking, putting your thoughts together, and we call
10:06
that sickness behavior. And they've discovered that that's because the mitochondria were activated by whatever happened in your arms, the legs, or whatever, where you were injured. And it's
10:18
recreating these chemicals, which are inflaming the brain, and interfering with energy production. And until that stops,
10:29
you have these problems, where you get over their virus, and the cell has a mechanism in order to shut it all down, and reverse it, and change it to anti-inflammatory state So the microglia can be
10:43
in an inflammatory state. That's called M1, or it could switch to a resting state, which is called M2, in which it shuts all of these things down and starts reversing. Well, a lot of damage is
10:57
done by immunologic reaction to viral infection or bacterial infection. And it has to be repaired where we found that these cells start secreting brain-derived neurotrophic factor. They start
11:11
reversing it, and they start fixing the damage that was done by the immune reaction. Well, in certain conditions, you don't allow that to happen. For instance, as Dr. Allison was saying, in a
11:25
boxer, he gets hit in the head, the microglia is activated, and starts secreting these damaging chemicals. But instead of letting it rest, he gets hit again in another boxing match or in during
11:41
his training and it produces. a worsening of this effect. We call it priming. And that increases the worsening of that effect so that instead of switching to that M2 anti-inflammatory,
11:59
it switches back to the M1 microglia, which is inflammatory, but now it's even more inflammatory than it was with the first blow. And if you know about boxing, the most damage to the head is
12:11
during sparring, not the actual boxing match. They can get terribly brain damage. And this is what happened to Muhammad Ali, because he was constantly sparring. They said his damage to his brain
12:26
was tremendous during sparring, and the microglia became more and more inflammatory, was never allowed to rest, and he eventually developed Parkinson's disease. But like I said, the part of the
12:40
brain affected in Parkinson's and is the highest concentration of microglia of any part of the brain.
12:48
Okay, this is, I think, what you wanted to talk about here. And this is your, you want to describe this as the microglia we saw before, then it becomes very activated and it's causing damage to
13:03
the neuron and all these other reactions are occurring. Can that help you explain a little bit what you want to do? Yeah, what you see is that switching, it's in the resting state, the microglia
13:15
normally, where it's not doing this damage. In fact, it's secreting things that help build and repair the surrounding neurons in synapses and dendrites. And then the injury happening and the
13:32
microglia will switch to an inflammatory state at the bottom and it starts secreting all of these harmful chemicals It's a crease gluten mate, it's a crease.
13:45
tumor necrosis factor alpha and looking sick the inflammatory cytokine that damages any surrounding neurons and apps axon
13:56
and so unless it shuts that down and switches back to the resting microglia then you get tremendous damage what they found in
14:07
one case of trauma to the brain the microglia were activated 17 years later long after the accident
14:18
in autism they did a study of numerous autistic patients up to the age 40 they found out that the microglia remained activated even to age 40 all the way from childhood and it was continuously
14:36
interfering with the brain's function
14:39
so we can see we see that this microglia can be activated for tremendously long time. Well, many of these flavonoids, like the catechins, the resveratrol, the omega-3 fats, and curcumin, they
14:55
switch the microglia to the anti-inflammatory state, and they lower a TNF alpha. And looking one bay is prevented from being secreted from the microglia And so they reduce inflammation, they reduce
15:12
the damage, and they reduce the free radical damage. Now you're into how we can inhibit the microglia activation I talked about, the finger cut I got, and obviously the cells are probably going to
15:26
remember that. If it's like a hemidolene, they keep getting hit in the brain, they just never recover, and they are in this chronically activated state, and not only that, but they become
15:40
hyper-reactive.
15:43
and that can lead to the damage, and then what you're getting into now is how do we inhibit, and this gets to all the flavonoids you talked about, how do we inhibit the activation of the microglia
15:55
because it's central to all this? Yeah, for instance, when I looked at omega-3 fatty acids, if you lower them, it increased inflammation. It increased the test, the C-reactive protein It was
16:12
increased, that shows there's inflammation presence. It increased the production of free radicals, just by lowering magnesium. If you raise the magnesium back to normal, all that went away.
16:26
And this is basically what happens in the body when you get a paper cut. The inflammation is part of the healing process. It's killing bad bacteria and it's releasing healing chemicals.
16:43
or interest in the brain, like brain deriving or tropic factor, which heals the wound. And once it's healed, there's a system that shuts it all off. The macrophages in your skin, where you got
16:57
the paper cut, are shut off. And the repair is basically finished, and it doesn't need the inflammation any longer. Well you can imagine, well, what if it healed and it remained inflamed? It
17:11
didn't stop. That's like what happens in your brain with Alzheimer's, Parkinson's. And such, you just have a sore spot on your finger with that paper cut that never healed. It remained inflamed,
17:26
remained destroyed. And then you would start getting ulceration, you'd start killing the cells around the cut. And that's what's happening in your brain is Here's the slide that you talked about at
17:38
the very beginning and here's magnesium
17:43
Dr. Bauch's discussion today will occur in five parts. First is the introduction. The second is the basics of cellular biochemistry and anatomy. The third is immuno-exciter toxicity and the
17:58
antioxidant system and specific antioxidants and how they work. Anatomy of the mitochondria and microglial activation and then a summary And 68
18:12
of the population is deficient in that substance, which is essential in the reactions you're just talking about. That's right. I mean, you just take a normal person, you lower their magnesium,
18:26
they become inflamed. The blood level shows a higher TNF alpha and leukin-6 and leukin-1 beta, the inflammatory cytokines your
18:39
CRP goes up, you see a reactive protein. If you replace the magnesium, that all returns to normal. Same thing with the omega-3 fats. If you lower them, the inflammatory chemicals, it came out
18:54
in kinds and
18:57
the
18:60
different inflammatory chemicals that are secreting the increase in content. If you raise the omega-3 fatty acid, they shut off and that all goes away So with this chart, you're seeing that the
19:12
vast number of the population is deficient in some of the most powerful anti-inflammatory and free radical scavenging elements. All right, here you are, vitamin C, vitamin A, calcium, where
19:27
folate, we just talked about that in vitamin
19:33
B12, folate deficiency, it produces neurological deformities in the fetus.
19:41
vitamin E. Look at that tremendous almost, almost up to 100 with vitamin E. So we come full circle. Actually, we started out telling everybody a little bit of how we got into the diets we're into,
19:56
how we changed from a farming society to an industrial society. We gave up our fish mostly because everything was mechanized and the food was mass produced. And
20:07
then we got into processed foods which are damaging to you. Some of the farm products we usually raised on a normal farm environment, we'll now contaminated with antibiotics and pesticides, which
20:21
we were ingesting. And all of this leads up to something that people didn't realize toward the end of the century, end of 2000, where they began to put out what your your dietary, not necessary
20:36
dietary supplementation should be. And that went into cereals you have, and they say the recommended daily value you should have. And many of those are underestimated, and you talked once before
20:49
about a pediatrician. And I think it was Washington, Seattle, wasn't it? Or is it Oregon? Oregon who
20:56
measured it up to large pediatric population and found that 100 of them were vitamin D deficient, 100 incredible. So, and this goes on for a lifetime. And you can then imagine what people are
21:11
talking about today about chronic diseases. It just doesn't happen because last week you didn't have enough magnesium. It's been going on for a while. So, I think you're done a superb job of
21:25
covering what they, and then the other thing is, you can overcome a lot of this by taking some antioxidants. which are common in the diet. They're in fruits, they're in vegetables, and so forth.
21:36
Sometimes you have to supplement them in higher amounts. You've talked before about vitamin B12, which many are deficient in, and you measure that easily the same with vitamin D, which you can get
21:49
by going out in the sun, and talked about various flavonoids, and we'll put all the titles on the slides so everybody knows. And it gets to the basic understanding of why we are having diseased
22:03
population.
22:06
And Robert Kennedy is talking about the increasing childhood diseases. And you've talked about this before because the vaccines are acting as another toxin to set off all these same reactions. And
22:23
you found that also in a form of diabetes. So anyway, I think it was a superb summary. Anything else you want to add that we didn't cover? I mean, this is, we're talking about a fundamental,
22:36
it's a medicine and an on over here, but anything the key that you think we should have mentioned. Well, you know, one of the things they've discovered was that even with minor surgery in the
22:50
periphery of the body, the hand or leg, microglia automatically activated in the brain And fortunately, when it heals, the microglia shut off.
23:03
Well, with the vaccination, you're artificially producing inflammation that lasts for decades. And the aluminum in the vaccine goes to the brain and produces activation constantly for your whole
23:20
life. So this is what Robert King is talking about just finished the paper and which I showed that you're giving these vaccines at the period 90 of the brain is being formed and I went through all of
23:36
the effects, what that has, how to alter the development of that brain and the physiology of the brain.
23:47
So we have absolute proof of these things now. It's all very scientific and
23:55
people are ignoring that Most doctors have never heard of it. They don't know anything about it. And that's why I've been trying to popularize immunoexciter toxicity. Get people's attention to
24:07
realize this has been well demonstrated and experimental animals and human disease, and it's virtually the cause of all neurodegenerative diseases and may have a great deal to do with other diseases
24:20
as well. I wrote an article for your journal, link again to auto-immune disease. that all autoimmune diseases are connected with high levels of glutamate being released in that area by the
24:34
inflammatory cells. All inflammatory cells
24:42
lymphocytes, macrophages, monocytes, mass cells, they all release tremendous amounts of glutamate when activated. And that's being totally ignored
24:53
by the vast majority of the medical profession. They don't know about it. Well, I want the audience to know that this is a concept that Russell has worked on for over 20 years. He's had some very
25:06
key associates who contributed to this. And
25:11
inflammation is the disease, the 21st century, as I've said it, it's been going on for years. Nobody know it 'cause you can't see it on an x-ray. You can't find it in any way, but as we showed,
25:23
there's 40 trillion cells, with incredibly incredible number of complex reactions going on that require all these chemicals to appear. It's like a mass production factory assembly line that they
25:38
have to have the engine appear at the right time and the tires and so forth so they can put the car together. And if they don't, they're deficient in the car won't work. And I think you're going to
25:49
deserve huge credit for in years to come for pointing this out to people as a fundamental problem. And you've also talked about what are the substances you can use that will counteract the microglial
26:04
aggravation and all these free radicals that are generated with the antioxidants that you can get off the shelf. Now, one last thing I wanted to ask you. In this, unfortunately, Russell, it
26:16
comes into everything we talk about but the pharmaceutical industry is out to destroy the supplement industry. so you can't get them from the drugstore. And therefore they control them. You wanna
26:31
tell people about that for a few minutes because this is a fight going on and it's a fight over money and control. You wanna talk about that for a few minutes and then we will wrap it up. Yeah,
26:43
this is something I've researched for a long time. I belong to a group of physicians who are studying this. And the pharmaceutical companies has always been the enemy of the natural supplements.
26:57
For instance, we were talking about probiotics for decades before mainland medicine had ever heard them, or admitted they had any influence. Now, there's tremendous research and they like to act
27:15
like they discovered it. We've been talking about it for decades, the importance of probiotics. Now it's a science in itself.
27:25
we discovered many things in medicine that they completely ignored. They had no idea what it was doing. The farming that we were talking about, deficiency in the vitamins, deficiency in the
27:38
magnesium, we've talked about for decades for over almost a hundred years. The medical profession totally ignored it. They still ignored. When I was a resident neurosurgery, we used to have
27:53
patients had terrible injuries to their brain. They would hang D5 and water, which is dextrose and water. They've got that for months. They received no vitamins, no minerals, nothing but that.
28:11
Then they would give them two-feed them after a while. The two feeding contained toxins, glutamine, various substances that we know increase inflammation into brain. lack of healing. And when I
28:27
was a resident, my patients got all of these things intravenously and they did four better. Unbelievably better than everybody else. And one of the general surgeons wrote a big thick book on
28:41
nutrition and
28:44
general surgery and it covers all of this. A lot of this. I learned a great deal from the book. For instance, vitamin C after an injury, the level goes to almost zero
28:57
and physicians totally ignore that. Where you've got a sick patient comes in the hospital. You don't realize they have no vitamin C. They have some of the chemicals that are absolutely essential
29:13
for life and they're ignored the whole time that patient is under your care. Giving medications that actually drain them.
29:24
They had patients who get demented because they're magnesium deficient. They would give
29:31
them this de-fiving water, and we know that if you increase carbohydrate intake, the thymine falls tremendously low, and they can go into a coma and die from it. That's well known, but well known
29:47
only among the biochemists and nutritionists It's not known by the general physician. And that's the problem is we've got all of these things that are well known, well researched, and they're
30:03
denying it, they're using drugs that are extremely toxic, they have a lot of side effects, and they're gonna affect the patient for error, and a lot of them, it's gonna kill them. And you have,
30:15
we have got a couple of videos that you made on the SI Digital website pre-operative and post-operative nutrition. I remember you said there because you worked on a burn unit that the people
30:29
post-operative with a regular surgery, post-operative are basically in a metabolic crisis which is similar to what you saw in burn patients, 30 burn patients. Did I recite that correctly? Yeah,
30:43
it was head injuries. And they found just a pure head injury, their metabolic changes were equal to a 30, third degree burn patient, which is tremendous. Tremendous. So I think this is a
30:58
fabulous job and it's an education in itself. We appreciate it. Well, you know, you're gonna be back to do some more of these. And I wanna thank you for everybody and thank you for this
31:10
tremendous insight into what is the 21st century major fundamental disease process You're mighty welcome. I hope that is an effect.
31:21
Okay, thank you so much Russell, appreciate it.
31:26
These are the key references in charge to this talk. Be prepared to take screenshots for your records that
31:34
you can use for subsequent information and as you refer back to this.
31:41
This is the antioxidant slide I just showed you at the beginning. Talking about the antioxidant system, made up of vitamins and minerals, flavonoids, and
31:55
antioxidants, and enzymes, and the very specific antioxidant agents which are very powerful menochrominatal kerstatin, omega-3 fatty acids, resveratrol, magnesium, and so forth.
32:12
This is a series of references to this talk. There's almost 50 references Take a screenshot. of this so you can use it for your records and use it to further look into these references.
32:30
These are references to 11 through 20 on the anti-accident system.
32:38
Take a screenshot here.
32:42
And these are references, anti-accident's three, 21 through 30, 29.
32:51
Take a screenshot of this slide. And the last three references in this anti-accident system presentation.
33:03
This is followed by a series of charts we refer to. You may want for your records and you could take screenshots of these also. This indicates the amount of nutrition that Americans have studied by
33:16
the US Department of Agriculture showing that the percentage of population not meeting the required daily amount, RDA, and you can see tremendous deficiencies in very essential minerals and vitamins.
33:41
This is a slide which we refer to showing over 100 years, 120 years, of the various nutrients in the soil, phosphorus, selenium, copper, magnesium, cobalt, calcium, zinc, and iron are
33:56
depleted with new firing methods. And also, in addition, there's herbicides, pesticides, and fungicides, adding to your diet and subtracting a central nutrient you need to make all these
34:10
chemical reactions go.
34:14
This is a slide of a
34:17
cell showing the nucleus and the blue and the various structures in the cell, which are responsible for making the proteins. With a little small mitochondria, which are the energy factories, which
34:32
drives that cell. There could be up to 100 mitochondria in a very tiny cell.
34:40
This is a more detailed look at the mitochondria which Dr. Blair liked discusses, showing our glucose gets into the cell through the membrane and is metabolized to pyruvate, which then gets into
34:53
the mitochondria in itself,
35:08
a tricarb dioxide cycle, which eventually winds up making energy that drives all of the equations and all the reactions that are going on in the body.
35:15
This is a slide on what happens with microglial activation and how this precipitates a response with various chemical substances secreted, which can be toxic and activate the cell or damage the
35:30
neuron. And he talks about those with a list on the side of the substances released.
35:38
And this is a slide we showed you on a series of events that occur with microglial activation when the
35:48
white cell or the microglial cell is activated in a central nervous system and go through a process of secreting and. making all kinds of chemicals, some of which are very harmful, some of which
35:59
are sending messages to other cells, eventually lining up with free radical generation, which our substances are very active and can destroy, all these chemical reactions that are going on in the
36:12
body, eventually can lead to mitochondrial dysfunction and immuno-exciter toxicity, which he, a term or she coined.
36:22
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