0:08 Hello, I'm James Ausman and I'd like to introduce you to the next speaker,
0:16 Jao, Ping, Rene, Boucher, Chairman of the Institute, Orthopedics and spinal cord and hand reconstruction in Kang hospital, and then in China, he and his co collaborator Sergio Canal, kind of arrow from Italy have worked on repairing this. While cord, which is after traumatic injury, which is something
0:44 people thought was not possible,
0:47 they've done research on this for over ten years, and now have reached the point where
0:53 they can demonstrate that this can be done successfully in animals from mice all the way to monkeys, dogs,
1:04 and Er, I have done some initial. What attempts in humans was chronic injury? They'll talk about this
1:14 Nobel prize work work that I think deserves the Nobel Prize because it goes against all the traditions of what people believe about
1:26 paralysis after spinal cord injury,
1:30 they been able than acute injury models with shark dissections. And immediately application, the opposing ends using a glycol protein, bridges
1:47 and electrical stimulation to provide animals who can walk within days to weeks to months and have excellent recovery.
1:59 This is very important work
2:02 Xiaoping are speaking in English. He worked in the United States for fifteen. Years at the transplantation center in Kentucky, some of the talk is a little hard to understand, but if you're watching the video,
2:19 I think you'll be able to get the message very easily, and if you're listening on audio, essentially with the outline, I've told you, you'll hear what what has been said. A reference sisters work can be found in surgical neurology International, looking under. Shopping, Ren and Sergio, kind of errol, hope you enjoy it. Thank you,
2:45 plus all I wanted to say Sign here off of her face to talk to all smiles and eyes. I also, the today this opportunity to gave me a decent Southern Maine is time to preside What am I achieve to duels the spinal called
3:05 fuels and technique. Okay, he endured, the Southern base are going to preside as thirteen fallen, called a faulty slides and several videos, so, although some pond either solve all summer technique, I only a brief millions. What he was he. I leave some crescent, Father, nice to have that southern, maybe Chicago corsets so first of all today, I gave these preside that of the concert, and a clinical transformation of Spain, call them. Wilson and the also this technique or that this concept
3:43 is call Jimmy made per household waste in China. Most people like call the spindle called Fuse it What I, What recalled, though that the same technique
3:54 before and conquer have an actual. You'll think that's the fields Flyers Begins with Yuzu. Whole, am I. What am I gonna be what of my bank wrong, I am micro surgeon. If all this is us thirty years ago, go before I moved with that state, as my car sudden, my professional feel that these highest transportation and atoll, second and talk under the top, try agreed a graph
4:23 on that slippery. Yes, you can from the slice of salt. Since My my yak medical school, I, how tiny about the time, yes.
4:38 The the familiar and alphabet are attend you as a Pdf. You know China, now multiple units, state I work at these last several university, then worse with a mobile, and as is not going to work, she got on the front and a Loyola University Chicago number back to China Tool.
5:00 All these critical triumph was spent of carbohydrates, feels it.
5:06 I dislike us soul. What my?
5:19 though you know, my past took a yes.
5:25 Baker and a research field. What am I doing, and what am I contributed? But it's the medical field.
5:33 So for the A talk about our face of an item, say spite of call the third -year as we know, Spaniel called the injury is not only also be the extra babies. Pizza is a whole medical field, Hi, all Pdp and the mortality medical property Iowa so far. At least so far reconceived no effect. My third candidate critic yesterday was read
6:02 from the lethal wreath wrap. Reveal we can see units lead you see, year after year, How plenty southern your case. China is the Ola hundred, southern your case, so calculate in the global Twenty million case.
6:22 So, yeah, us neither at least seven billion a year for the spinal call the injury.
6:33 Hi law, Father, say General is a medical problem. Pasta hundred years. I, while the balls can a maker and a research reno Nv
6:48 technique to surrender medical problem. Why our actual use in these this simple select, too, So the symmetrical proper that's changed Chandra useful, we can see from the slice you see this in your neuroscience, Hey Francis Vinyl call. If you're sat environment the class that you how to connect how to rebuild how to reconstruct
7:19 connection of your interview till facilities, Visa, Asia, Kate yourself,
7:30 If we reveal every reveal, because See
7:36 Futsal past hundred years. I used some dessert
7:41 to top this. I see all the medical field. What Iowa, East Weiss orthopedics thunder on your surgeon to the same kind of medical procedure to sir, Ruled Savannah, call the injury. What Sb. All reduction. Internal fake have tasted Father. Whatever a bolt
8:05 lie release, Savannah caught price. As only read what, I, what attack, either it, the vital for the past hundred years
8:16 and the past attendee, Our city, Yes stem site is where a hobby. You, so getting to work, we them am Soc. Sec, I fought trying to salute spinal cord injury, but has so far at least to be conceived. So far no
8:38 good debate. Since the Lord, this medical profit, so today we talk about babies, that new medical surgical approach or technique concepts, recall number, refusing technique yields in the high plenty of ethical political contacts to fuel. Send it your sights,
9:04 so they slice a couple of years ago, my friend. Thirty of that kind of work. He come to United States.
9:14 The gale, our university prejudice or use the strike to solve the set your technique about a spinal, call the fusion, Gmt per cultural Desert. How either you're a fundamental father, Savannah, call the fusing technique for the deep out you from Mesa, and another davies, We already poverty east to Southern sixty years surgery and. As I trundle into Southern Nineteen,
9:49 so what are these the idea if we using the send home to stay with simple words to say?
9:57 Everybody know.
10:01 If spinal call the injury, we always think about the Primeval Dweik interrupt the suns, were the central Euro. Sentra signal cannot from the three to the in between meetings, so Diesel be called primed. They'll track everybody you know, Wow, Pyramidal tract practice, Is this your password, How Iowa young Dynamo?
10:30 I will a sacred Europe, possibly Rican, cop, simple cup call with a cocker Spaniel tracks through Spaniel Spaniel Euro. You've done your seats, That could these me
10:46 anxiety, Father animal, while the fume it, the balls, and your past week on the body eighth have dismantled, Call the injury a crime. It all tracks. Barbara ether exactly to the interrupt, our spinal, call the fields and technique Title From this sweet little color, Spinal tract
11:13 reconnect this another Europe heartbeat
11:18 law Many cop, the bulls, Europe Cosby, his work again for the detail, noughties deal to the time limit of an audience that he was he random. If I were by the interesting to chat with Isa, our poverty cases
11:35 for the spinal, call the fields and technique are too many per helical. What a moto co marketed. I used this one slice to solve to Monica makes him so far excavated for the modern mechanism. Renata know where well for the detail by the January for the January to naughty to a karate. If the Euro style yourself injury, spinal cord community, the neuroscience has its natural heating system, precise like a bicycle. If ofcom to the injury to device and acoustic is involved, Does not nature. You are all keeping precise. All of the spangle. Call the fusing technique as used to place the pike.
12:28 Increase is a high before this is precisely get well,
12:35 so second, I, but it's a new concept. Why reusing visited Spain. Spider called the fuse, repeating to yourself, this nice homeowners, a nice camo six, as we know, smaller myself, smiles, smaller, smaller, fulfill, or no other entities, will we all use in these
12:57 contact? A nice commodities bought a spinal cord injury Because you. If we make cross texted, we can see the spinal caught Khomeini. You are a fibrous twenty million twenty million euro fiber of the cross section of the spinal call, so reusing this new concept to the scrappage and your technique,
13:23 Salt here, we talk about
13:27 the Gemini per Calico. Al spinal called a fusion technique. I shall be calculated, Larry the torn you. You're possibly begin involved, as three key, three critical cake could eat fossil is irretrievably shop transaction. To make
13:47 this spinal cord injury area is a thrice some face second, reused, The of fields, said
13:57 fields, and of me. His height we can see is the same Paul. Chemical structure of here
14:07 of we in third disorder, compared that electrical stimulation to hype for the all the basic, as that a research lab the lab study past sixty years.
14:24 You may keep, we already do. While the smaller animal mice re dog and a monkey, real politics, our these resets are the calm
14:39 in the several different journal,
14:45 So here I sold Visa, pre, clinical study is the dark distant, I, so
14:54 we can see his dog model.
14:59 They may. In the as he got.
15:02 He high level
15:05 spinal cord hundred percent comfortable. It
15:12 was cut using a sharp knife
15:18 later with a meteorite, A imagery using that pipe
15:25 cut out to fields in spinal cord of instrumental cop. Because see the dog balls, federal law like.
15:37 And eight weeks, four weeks, because he the dog,
15:43 the multifunctional recovery, Kowalski,
15:48 so far this study, we follow up two years. They poverty studies, a research study. This is a console bug. If rethought
16:00 fusion, Savannah, color fields said no functional recovery.
16:09 So basically the our team and our international collaborative
16:16 research study life study yet to Southern Nike, Sergio. The Asthma International collateral.
16:28 Can cause translate this to live study resource started to clinical saw. In two thousand and nineteen were established. They say is an international organization is the Kaaba, and it's so far we can say you end up global caltech. He is a saving independent research group already repeat this survey. No cobb fuels and I can eat. In Animal
17:01 Yang to Southern Nineteen, the T Cop Global Initiative to cure Paradise, A teacup at its is a psychologist, plus the clinical translational center You dining, you tryna my current hospital. Wasting your naysayer. The trap to the perverse, these connected through a design surrender, call the fields in cervical, perceived her second verified safety, and a critical of her ability with spinal cord fusion, Verify that the pie, toxic
17:43 false prove critical, facilitated our Savannah, confusing, Saturday, last provider sent every day. We'll help you make critical treatment. I'll Savannah, called the fuse. It
17:57 saw all the research clinical trial, all the reach of a debate as three coup, different, a groomer to identified, like this Lysol way, he fell off the piece, and different time, Father electrical vehicle he could join under International
18:18 your asserted Santis Dot. Kind of work
18:26 so these are our data, My case. After surgery, Le Mars. We can see the The Np. Electrical freezer odyssey. We can see the positive result.
18:41 Despite this, I saw this at another while
18:45 second case positive results.
18:53 Saudis, of all
18:56 what it, the trout, we collect all the data from this three -part clinical electrical result is on the immediate se ri, Sol days, I Imgur the T I the fields of kinesin.
19:18 we can see the first case before surgery, because the color spinal called exactly, call to me, interrupt, and a type gap between personal and a destiny, laundry duties case,
19:34 Translate reuse you. This a half percent Savannah, Call the white color, Help this vital, call it graft tool breed distance. I so we can see the case after surgery, spinal called connection again, You can't contractor connected phone, all but this this panel saw is the bias after surgery, Whereas the blacks because is and yours fabrics. These
20:09 reconstruct connect together. This is the second case. The why is a P. Eight label. Also refund up this case is half years.
20:25 So does the eighties, though another two case for the of track, we can see this. While these heart is still case, reveals the A's of feel, or not, as the sooner the or tool connect, connect, Savannah, cop, the big Dyke
20:45 second. Said so far. After surgery several months, we can see spinal cord
20:54 recalled. Try to federal. Caught. So far this the trap we started last year, Much readout D C at April tells me we already through twenty case,
21:07 Joel, the candy case, almost all the case we can see from the images, the positive result.
21:19 And another using twisty result, recall called Central Pit as know spinal cord injury may pcyc. At least the our twenty piece. I, How have a son, Kyle, Central pit, The Central pit, some, and if reusing?
21:45 Severe, why is time? The skylines of crime ring? Yeah, I'll attend a piece last case, though the central Pier cancer difficult it release,
21:58 and a decent, all data rich Auc analyses, father, stammered,
22:08 sole heel, result couple of case, after spinal, called the fuses. Holly's the spinal cord fusion, after surgery, rehab and recovery of a patient
22:25 say after surgery, when the pacing because. You're the leader records that songs.
22:34 What a seasoning true functional training every day.
22:43 This is another case. The patient before surgery, we can see before the surgery. Is after surgery,
22:56 hit a sizzling, the walk
23:01 can then up under what cover hours at least?
23:11 We do these cutting through all the time. The case, Savannah called The injury is on the sarcastic language, and the A's are completely spent a cop injury
23:25 or decent, These caves. The Aids, Imgur, the T I sliced the soul distant Pre, Alvarez Reason, Rick and his spinal call also.
23:39 We do this. Why. Because these wired low level reuse the perfil now is to know about is of a sudden, Lela. This skype is a sending the way to the perfil or no, transfer their Pc to breed Savannah, called yesterday, after surgery, This Vps, I is the after did one moss where you can seek a spinal call
24:08 Christology. Is reconnect to get
24:13 this a another case.
24:15 This is not a case. This case is Laurie in Cst, so thighs after surgery
24:23 after slathering six months,
24:28 He's a Sarah Siegel, Asa, Hundred percent Company, three injury, We do also read to the use of perfume. No transfer the cases. To reconnect spinal car hit his spinal cord injury, or about the diet about six centimeters, so these societal is that the pizza after surgery six months come via hospital. Follow up exam. He is a dream, then pair Bill bah a C -span rehab and efficient walking tree, Because see the slice.
25:12 The so he can watch it, at least the cabals, default surgery. He cannot do that this piece, and
25:30 beside the functional, the most functional
25:34 Kravitz. Also, he fell significantly.
25:50 It is our another one exciting result founded cutting the track,
26:13 Okay, so these are Imgur, the T I. He's just disappear. Free operation on the pulse of altruistic, We can see the sly assault, exactly big guy.
26:26 You need a survey. We might have a tasting the both.
26:45 Re using stanza neural factors, growth factors, All Isla Island biology. Egypt's not work. Because masterpiece of me to just twenty piece, it
27:02 to Ivan spinal, cut. The cake is a god. Sakes, the same centimeter of the twenty case, says Send of the.
27:15 So far this cradle, try it. What guy from pieces come this opinion, rehab to the first salute the
27:25 connection reconnection
27:29 Make I see, after surveying the case, retooled his perfume that our reconnection so that patients come back at these days the six, not six month, though Moss come back, We repeat the dea. We can see the final call.
27:45 Exit is a staple acts were good.
27:52 So far this trial
27:55 customer here because they say he's not a final result. Long kind of study. Yeah, steal your phone or I'll redo first one fewer case already one years after serving last, Wang sat down to surgery. One last saw all the regents, the either. Warming up and the orbiter reached it, but at least the sofa from the twenty patient we can guide, Follow up, conclusive this vital call the fumes and kicking even design is a reasonable all spinal, called a huge, repeated, No company cases, obviously in these trap
28:40 survey them called the fuel said. If he was it.
29:48 Okay, so today these are all my clinical trial and the parade Monday, Indycar, correct critical resource. That is, so I already time to repot last of what items. Thank you made these the balls
30:04 preclinical research that'd be keep in finance with his path. Yeah, I mean by local university for the clinical trial pod. I finish it off in the long sheet university. Solar per se, this Kabul make radios to do that is by silver to potatoes and a super job.
30:30 Okay, the
30:33 I would like to sample widely by the comments while, but getting
30:39 all tools are easy to understand. Why isn't the artist covering the point to discouraged now,
30:50 And also, Yeah, I would I truth fruity grapefruit that alzheimer he will allow.
30:59 I think green combat. Though our started like did I did for for our my article, He sang
31:09 the ground tiled your pond had not a thought for the spinal cord
31:16 injury, Not to be true, Visa the face valid, I went, and the albatross reason of the experimental work from the kind of world and targeted. And apparently cottages either work
31:34 under. I'm pretty. He's a comment.
31:39 This a another my
31:44 favorites, precise her eagerness to Michael. Shot. He's the aided in surgery. Hey in couple Arla research study. He gave a decent. I just wear a notice. Read all the power and the priest, crispy. He's the common, while research static.
32:06 The automatic.
32:09 Thank you.
32:11 It felt very surreal of origin. James place. Jumping.
32:18 I like to. We have fifteen minutes, but I. I think I'm gonna ask what I think the audience wants to know Dr. Osman is joining, but he has still hasn't.
32:27 Been on yet so. If a doctor cannot, really, if you want to go ahead for a little bit till he's there. That would be excellent. Okay, Hear the moment we could have Muslim. Get my apologies. Can I speak, Everybody can hurry. Yes, We can hear me
32:47 for years, my question what you've shown over five or ten years. It is first of all we know. We've been taught history years that somebody who has a spinal cord injury complete does not recover. We've all been taught this as doctors for decades.
33:08 Ah, and so it's difficult to accept that we have recovery, but you've shown in mice is shown in rats, you've shown in dogs, you've shown in monkeys under an experimental condition, if you sharply transect the spinal cord. You will be prepare to put it together. You'll put shoes adjourns. Would allow the cell membranes to stay open during the period where they are they. The The membranes are approximating you do electrical stimulation to encourage the nerve factors, shoe girl, and in the animals you shown as you showed, just showed the dog today. But there are videos of the mice who walk within a week or rather watch within a week, and and you've just shown a dog and you've got to work and monkeys it. There's no question that scientifically shown that works, and you have done studies showing that diffusion tensor imaging shows growth of neurons across the gap. The question God surgery, Which everybody knows that. If you interrupt a pyramidal tracts, you can't get them to regrow. Can you tell the audience about what you're thinking as amount of physiology and growth across the great gap or the enter? If non chill neuron, the short neurons between segments that really exist in the primitive spinal cord and contrary contained the message. Can you can you explain that to the audience because that will make them understand what's happened?
34:48 Absolutely thank you, Jim for introducing this Because this is a very important thing. Now. Let's put into perspective at all. That has been said, and much more first of all as Jim just said, we all have been told that when you transact a chord. You are just getting nowhere. I mean the patient will remain paralyzed. Of course, spinal cord injury, severe spinal cord injury that really interrupts everything is just like a spinal cord transection. Solve the problem. Here as everybody knows is Gemini was introduced for head transplant, so he was introduced for an acute. And acute in dimension on a severed spinal cord, that really does not apply to spinal cord injuries, so that the reasoning was that can these be sought of deployed in some way to cure spinal cord injury, so there aren't first of all, we had to change our anatomical view, while everything we've been taught is simply to be lenient off. I wouldn't say wrong. I would say incomplete, which is more diplomatic or so if we ask anyone, and he referred you out there. Who what is the anatomy driving our movements? We will reach Receive this sort of
36:15 truth that the brain is transmitting all impulses through why matter tracts, including the pyramidal tract, which actually in the ann connects with. Modern your ass and dessert than the modern era as they make us move, but what really counts is this linear connection between the modern areas and the modern Europe, via the pyramidal tract. Now we are know for a very long time that this is not the picture the paramo trek is out there to actually enable. Fine movements, but work done by functional neurosurgeons over the years, and especially until the seventies clearly prove beyond a hint of doubt that what really counts is the grey matter. Now every medical student will tell you, of course, and every neurosurgeon to the grey matter. Is there just do we know process reflexes etc, etc, Which is absolutely wrong? There is a pathway that we're know for a long time that actually starts from the brainstem and goes all the way down into the spinal cord in the proper style, mash work the grey matter that is truly responsible for this, and now you will exit as I add more details. From shopping trial, you will understand how it is, so this is going to really blow you away, Because this has gotta be stunning, and so let's go back and less dry. Understand how to deploy this for spinal cord injury. Every single neurosurgeon starting in two thousand and thirteen told us this is going to wear first year to prove that a spinal can acutely. Transected spinal cord can be mended, and that has been done as you. You didn't Shelby didn't show you the private videos, but you can find them easily on Internet, and they are even more astonishing that the dogfight
38:24 so, and acutely acutely treated transect interest. I can spend a gore can really restore moderate sensory function that is out of the question, so everybody who said different was wrong. Now the only way to deploy this for clinical or injury is going back into our past, and the year is nineteen, forty four, nineteen, forty four, an American neurosurgeon Dr. Boozy published a seminal work about the first case of spinal cord transplantation what he did and at what shopping date was transect in removing an entire segment. At the injured spinal cord, so off, it goes like few centimeters, a few inches, two inches, or even more, you remove the injured spinal cord, and that's gone. What you get is a gap. Now everybody is familiar away to attempt at filling in this gap. But the only way to fill in this gap is gone. The way was a showdown decades ago transplant in a segment. Spinal cord that came into stages shopping covered stage one. The idea was okay, We, if we remove this injured segment and we replace it with something else weighed a healthy segment, but before doing that, we want to be sure that since the level to defuse are two proximal and distal, yet to be sure that this really works, so what shopping dead was simple.
40:07 I will give you more details about this trial. He simply split the corridor and there is plenty of anatomy, and they will explain why the progress, spinal grey matter pathway so important. He's played a segment a hemi, a heavy cord, so imagine that cord, the cord is split the cord into and longitudinally, and he turned over the segment of core to fill in the gap. And he kept it vascularized, It means that, and all the time this segment, autologous segment, Accord was kept basket arrives at this mind. Two things were necessary,
40:47 a blind tag,
40:50 so step number one and see what happens if he would be the same as with saw monkeys, or he signed dogs, or rollins, etc, and number two. Establishing the parameters for spinal cord stimulation in order to accelerate the thing by the order to have a rational trial. The first thing you wanna do is seen what happens when you apply pack, so he did two things for Thor in all the patients and a happy and rest received the surgery, where thoracic, okay, not cervical. For now, Thoracic was just proof of principle, So for upper thoracic and I repeat upper thoracic lesions. The technique used was to turn over a hemi segment of the cord in order to feel the cat the gap, while for lower thoracic, it
41:43 of shopping preferred to use a very old technique that as being employed for a long time in the past, especially in animals, and I remember when I started this from the eighties, that has been plenty of talk about that using printful nurse. Its and that has been done abhor using our technology. It over the decades, so he just inserted disapproval, nor from the sooner, and the problem was just Make it work, so initially he had like Pag and the results are that whether you inferred soul nurse, plus bank, or whether you use a hand picked group of cord blood bag patients recover. But the question now is an anatomical, and this is why James and Trod is absolutely on time and let me explain. Everybody now imagine the court. We all been told that the corridors that nice butterfly, and the why matter with twenty million fibrous all around that now imagine splitting the cord longitudinally So you've got two hats, now imagine bringing one part. Below know what comes to mind is that, hey, but that's all topsy turvy topsy. Now, It's not gonna work. He can work, and you will be right. If and only if the traditional teaching that we all recede was right. That is why matter of your ammo track, but says that he's wrong the entire recovery hinges. In the gray matter on the proper spinal pathway, Why because it's bi -directional so, even if you are really up in Deaton the normal anatomy, and you use the same chord and let let's be clear. You're using half a cord the bridge and what is left of the card, then donated half of a segment. Actually is after segment, so it's not have the course of what you saw in the videos is actually half a cord working with a bridge in between and the pag. The pag, plus fun. Of course, stimulation cases will be presented separately. I can tell you that A the ads, but for now the rationale of this trial was to prove that you don't want just to amass all the stuff together. You want, just go step by step. So the first day was disproving the pig was enough both way that the court segment the court graph and digital, nor grabbed. Where
44:32 are your or because we we've got to time. I'm in here, but I, so, what would you have done and what jumping is known what you're talking about is the circular they're speaking illogically is that the short neurons in the gray matter or bridging this gap. And that's what we see in the in the D. T I imaging. That's why we see the electrical impulses going through, And that's why they see the successful. So what we've done or what you've done is basically restored the primitive motor system or taken advantage of the primitive motor system in man, which is in animals, Multi segmental is that correct, if if you cut
45:17 If you cut a worm in tuning a car, it's multisite mental job. I think the audience needs to understand that what you've explained it is a very good detail, but that that's the explanation obviously from the work you've done and animals. It works, and that's the reason it works. You're doing work in humans, and and and what's your opinion shown is I think very dramatic after look at this from a scientific point of view. There's been a huge amount of science and studies behind this and we're trying to solve what shopping started his talk with was a huge, huge, untreated, absolutely absolutely world health problems, now absolutely have one quick Jima question from the
46:06 right and the one question from the audience, and that question is is, is there a role for nerve factors in Mile Malaysia? Or even in resected areas of Maya, Malaysia, at some point in the future, all that's a good question, and so I can't complete my, My my short presentation shape all circuit That
46:36 what he's thinking about that we and shopping shopping, just mention a paper we published in Surgical garage International, just covering this. All in, we can't tell you, this, and dealers must be very clear over the past forty years, stem cells, nerve growth factors. Neuron growth factors are all manner, on the growth factors have been employed in animal models, All spinal cord injury submitted to spinal to full transaction. When we compare data from thirty years a leader cha, we were. The result was absolutely yeah, and one to first tag is more effective than anything that has been deployed up to now and two, It is by far faster because you want to do it fast Buddy tape, Bang, Bang, mean we want to pay my main polyethylene glycol
47:35 molecular. If that that keeps the membranes are open during this period of repair, Okay, well, I'm launching a new pronunciation for bag, and don't like the G. So expect
47:48 you all like it button
47:51 the needle, such as asked, and it is very important about peg, so let me give you more about that pag. And people in February your searches. When the United States asked me. Okay, you flush that we'd peg, But we. We don't understand. Well. How does it work? I mean it's it's it's liquid. It's it's what the paga is. Not all packs Com equal are equal to the eyes of God. It means that there are certain molecular weights that are more effective than otters. I can't tell you that the six hundred and fifteen one hundred bags are the most effect. What is absolutely important is that. Viscosity increases as the molecular weight increases, so when you just flash your, your interface tag will stick their okay. If it's not magic, it will just do that automatic number two, and eat more important You heard about pag an allergy
48:49 during the spirit of dynamic, of there, being a few cases, all the pag reactions, even an Apple access. And so the question is is back, Save absolutely. Yes, Let me tell you the data from the literature over the house. Yeah, Let me not here because we're getting wrong, and I wanted to ask the panel if they wanted to ask any questions. I think absolutely they would have. Their scientific work has been no visible. Okay, Let me that scientific work has been done showing a pagan, various other choices, Janina and the polyethylene glycol is effective. Always is in the literature. All of this has been done. Factually. Let me ask the panel author. Alexis. Ah, what what quote we have to make this short? I think we should only have about five minutes of short questions. Short answers. Any questions you have for a, so I can make. I can just make quick comment. Yeah, so it's very easy to be dismissive of the world than Chopin and showed you talked about because it has not been done. But go back in time and sing about Yamanaka Shinya Yamanaka, the Japanese Nobel Prize laureate, You know, he started to look at the transcription factors, and I remember myself thinking about those things. When before it was discovered, it's impossible to produce Id? Is it possible, Swear? But just for factors did that affect right, so that's one thing one has to them, but we should not dismiss the number number two is that the? Why would peg work? Because you know, in acute T the the lip. It has this ability do close up on itself. It will make themselves. So. If you put, If you put the lip at molecules made from a leopard membrane and put it in water, it will make it real close itself into Miss. So once things are cut, Internet course in an actress environment, the ends of the the severe exons the clothes on themself. Now what then does it just leaves it open for awhile before the other factors start to work on it. Nobody has seen it. This is just a conjecture, but it seems to work the word of caution that that needs to be here that you know, although we don't want to dismiss dismissive, but there has to be caution that for a couple of decades, you know, remember the time when when Schwab Martin Shaw from Switzerland came up with these Muslims, especially glycoproteins with her son grow growth. No, Yeah, and then and then we use the Wii. U's one of the antibody antibodies, and I. I think I remember something like that, and it did show some growth in mice, but then we cannot go beyond that showed the ability for lower mammals. Was his ability for lower invertebrates was sensibility. For a. You know, I'm a little more Terrorism was what says Lower invertebrates is different in terms of regeneration, but the answer has to be here. It's a matter of lot of trial and error. But the is here and I and I was very impressed with what search you have just mentioned, But it just opened up. You know one under window in my in my mind about this idea of actually the connection to the grey matter, because we always think about the white metal ring, all the function. We will lose that major function, but then the grey matter connection, which is polyphasic, a poly synaptic that can start to do some effect, and that's what we saw in Chopin's results, so those are my comments cushion. Washing the cushion, but don't be dismissive.
52:26 Thank you. That's great comment, and I would like to add. If you, I, I actually a non schwab. But in order to give you that he put into perspective and wish Father really like basically every other guy in the S. C. I feel over the past forty years, I believe that you can't really keep the consumer. Spinal cord entities, and then approach it with antibodies, or whatever we all know about this here You are removing the primary cause of spinal cord injury. You're removing what stops the entire growth scenario in the spinal cord, and you replace it with something that is healthy, number one. Number two as a nation bullshit, Ninety forty four, did this first experiment on a on a young guy who just had this throughout her thoracic spine, Grand jury, Remove the entire segment. Replace that with that kind of Eric. Segment. Of course it couldn't work, but the fact is what we are proposing, and it will be out shortly as an editorial spinal cord injury thanks.
53:46 We are the dryness Men is our our definitive proposal for a cure for spinal cord injury, and at ease, a hetero heterologous spinal cord transplantation. But it is absolutely true what you said, We had to be cautious. Well always, we had to be cautious, but after forty years of failure, and in industry, viewed already been out now shopping prove that. Yeah, yeah, there's no question. I mean. After forty years that you failed to produce a cure. I mean it's crazy, so now we get to think different, and we thank Professor Osman for letting us think different and just saying so, but let me complete the allergy thing Because people are concerned. Some people are concerned about the attitude from heck because
54:41 I want to allay your fears over the past forty years. Forty years there is dina. No more than eighty cases of anaphylaxis after injection, all about high molecular weight pegs. So it's not the kind of molecular weights we are using here, so this is completely safe and that's that asks will be said again. It is. It is simpler than a stem cells. I think said you're in my mind, Peggy safer than a stem cells. I seen a more pronounced the stem cells transplantation
55:13 tradition. But what make your rubbish doctor? Because? First of all that
55:20 let me stop everybody here for a minute cause they. We have a huge audience to hear
55:26 what you heard this morning in these talks. Is it is very groundbreaking. You heard Tony to solid chunk about where neurosurgery is going to begin the future. It's totally different than where we are now. I. I used to give talks around the world that neurosurgery by the entity. Near the end of the century won't exist as we traditionally know it. Tony was telling you that this morning I would circle and and cow pig jumping. You gave an excellent talk on excellent evidence. I know you've you've worked extremely hard in this, and and I know Sergio. You've you've taken a lot of criticism for what his outstanding scientific work. This is another change a break in what traditional thinking it. We have the potential. To shove spinal cord injury and pain and paralysis, and that's the significance of those were also had other sessions this morning, Terrific session on spine on epilepsy and tumor. I hope the audience enjoys us. We're gonna leave the session and then have some a few closing tracks for one minute each and then we want you to network. Sergio and jumping will be in the in the lounge at a table. You can go talk to them. Virtually You can find other people. You haven't had a chance to meet and talk to them. Virtually This is the chance to meet and talk with people who got plenty of time after that. We're just going to make a few comments here and then we want you to go network. So thank you gentle, paying. Thank you very much. Sergio. Thank you for your comments. After the. I'm sorry, we didn't get you, but you're knowledgeable in this, too.
57:13 Always your dog asthma.
57:16 Okay, thank you.